Critical reviews in oncology/hematology · 2024
Dietary restriction and hepatic cancer: Systematic review and meta-analysis of animal studies.
МетаанализСистематический обзорСтатьяНазвание и аннотация: Перевод пока не подготовлен
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de Sousa Dallyla Jennifer Morais, Feitosa de Oliveira Kynnara Gabriella, Pereira Irislene Costa, do Nascimento Glauto Tuquarre Melo, Barrense Clenio Oliveira, Martins Jorddam Almondes, Pereira Rêgo Beatriz de Mello, Oliveira da Silva Tiago Eugênio, Carneiro da Silva Felipe Cavalcanti, Torres-Leal Francisco Leonardo
Аннотация
The effect of calorie restriction, fasting, and ketogenic diets on the treatment of liver cancer remains uncertain. Therefore, we conducted a systematic review to evaluate the effect of restrictive diets on the development and progression of liver cancer in animal models. We did a meta-analysis using the Cochrane Collaboration's Review Manager software, with the random effects model and the inverse variance technique. We examined 19 studies that were conducted between 1983 and 2020. Of these, 63.2% investigated calorie restriction, 21.0% experimented with a ketogenic diet, and 15.8% investigated the effects of fasting. The intervention lasted anything from 48 h to 221 weeks. Results showed that restrictive diets may reduce tumor incidence and progression, with a significant reduction in the risk of liver cancer development. Thereby, our results suggest that putting limits on what you eat may help treat liver cancer in more ways than one.