Nature genetics · 2010

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.

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Wang Li-Dong, Zhou Fu-You, Li Xue-Min, Sun Liang-Dan, Song Xin, Jin Yan, Li Jiang-Man, Kong Guo-Qiang, Qi Hong, Cui Juan, Zhang Lian-Qun, Yang Jie-Zhi, Li Ji-Lin, Li Xing-Chuan, Ren Jing-Li, Liu Zhi-Cai, Gao Wen-Jun, Yuan Ling, Wei Wu, Zhang Yan-Rui, Wang Wei-Peng, Sheyhidin Ilyar, Li Feng, Chen Bao-Ping, Ren Shu-Wei, Liu Bin, Li Dan, Ku Jian-Wei, Fan Zong-Min, Zhou Sheng-Li, Guo Zhi-Gang, Zhao Xue-Ke, Liu Na, Ai Yong-Hong, Shen Fang-Fang, Cui Wen-Yan, Song Shuang, Guo Tao, Huang Jing, Yuan Chao, Huang Jia, Wu Yue, Yue Wen-Bin, Feng Chang-Wei, Li Hong-Lei, Wang Yan, Tian Jin-Ya, Lu Yue, Yuan Yi, Zhu Wen-Liang, Liu Min, Fu Wen-Jing, Yang Xia, Wang Han-Jing, Han Suo-Li, Chen Jie, Han Min, Wang Hai-Yan, Zhang Peng, Li Xiu-Min, Dong Jin-Cheng, Xing Guo-Lan, Wang Ran, Guo Ming, Chang Zhi-Wei, Liu Hai-Lin, Guo Li, Yuan Zhi-Qing, Liu Hai, Lu Qin, Yang Liu-Qin, Zhu Fu-Guo, Yang Xiu-Feng, Feng Xiao-Shan, Wang Zhou, Li Yin, Gao She-Gan, Qige Qirenwang, Bai Long-Tang, Yang Wen-Jun, Lei Guang-Yan, Shen Zhong-Ying, Chen Long-Qi, Li En-Min, Xu Li-Yan, Wu Zhi-Yong, Cao Wei-Ke, Wang Jian-Po, Bao Zhi-Qin, Chen Ji-Li, Ding Guang-Cheng, Zhuang Xiang, Zhou Ying-Fa, Zheng Hou-Feng, Zhang Zheng, Zuo Xian-Bo, Dong Zi-Ming, Fan Dong-Mei, He Xin, Wang Jin, Zhou Qi, Zhang Qin-Xian, Jiao Xin-Ying, Lian Shi-Yong, Ji Ai-Fang, Lu Xiao-Mei, Wang Jin-Sheng, Chang Fu-Bao, Lu Chang-Dong, Chen Zhi-Guo, Miao Jian-Jun, Fan Zeng-Lin, Lin Ruo-Bai, Liu Tai-Jiang, Wei Jin-Chang, Kong Qing-Peng, Lan Yu, Fan Yu-Jing, Gao Fu-Sheng, Wang Tian-Yun, Xie Dong, Chen Shu-Qing, Yang Wan-Cai, Hong Jun-Yan, Wang Liang, Qiu Song-Liang, Cai Zhi-Ming, Zhang Xue-Jun

Аннотация

We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.

Предметные рубрики MeSH

Aged Asian People Carcinoma, Squamous Cell Case-Control Studies Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 20 Esophageal Neoplasms Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Membrane Proteins Membrane Transport Proteins Middle Aged Phosphoinositide Phospholipase C Polymorphism, Single Nucleotide

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.

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Аннотация

Предметные рубрики MeSH