Nature genetics · 2010
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
СтатьяПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Abnet Christian C, Freedman Neal D, Hu Nan, Wang Zhaoming, Yu Kai, Shu Xiao-Ou, Yuan Jian-Min, Zheng Wei, Dawsey Sanford M, Dong Linda M, Lee Maxwell P, Ding Ti, Qiao You-Lin, Gao Yu-Tang, Koh Woon-Puay, Xiang Yong-Bing, Tang Ze-Zhong, Fan Jin-Hu, Wang Chaoyu, Wheeler William, Gail Mitchell H, Yeager Meredith, Yuenger Jeff, Hutchinson Amy, Jacobs Kevin B, Giffen Carol A, Burdett Laurie, Fraumeni Joseph F, Tucker Margaret A, Chow Wong-Ho, Goldstein Alisa M, Chanock Stephen J, Taylor Philip R
Аннотация
We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 SNPs. We report a combined analysis of 2,240 gastric cancer cases, 2,115 ESCC cases and 3,302 controls drawn from five studies. In logistic regression models adjusted for age, sex and study, multiple variants at 10q23 had genome-wide significance for gastric cancer and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34). The association with gastric cancer differed by anatomic subsite. For tumors in the cardia the association was stronger (P = 4.19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China.