Gastrointestinal endoscopy · 2010
Short-term safety and efficacy of the Trans-oral Endoscopic Restrictive Implant System for the treatment of obesity.
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de Jong Koen, Mathus-Vliegen Elisabeth M H, Veldhuyzen Elisabeth A M L, Eshuis Jan H, Fockens Paul
Аннотация
BACKGROUND: Medical treatment of obesity often fails, and surgical treatment, although successful, is aggressive.
OBJECTIVE: To evaluate the short-term safety and efficacy of an endoscopic restrictive implant procedure in the treatment of obesity.
DESIGN: Prospective, observational study.
SETTING: Tertiary-care referral hospital in The Netherlands.
PATIENTS: This study involved 13 patients with body mass indexes of between 40 and 50 kg/m(2) or between 35 and 40 kg/m(2) with obesity-related comorbidities.
INTERVENTION: A new transoral endoscopic restrictive implant procedure in the treatment of obesity.
MAIN OUTCOME MEASUREMENTS: Safety of the procedure, percentage of excess weight loss, change in body mass index.
RESULTS: In 1 patient, the procedure was abandoned after a gastric perforation related to stapler malfunctioning. In 2 patients, pneumoperitoneum was detected. This was desufflated with a percutaneous hollow needle in one patient and treated conservatively in the other. After these complications, technical adjustments were made in the procedure, and no subsequent procedural complications were seen. At 3 months postprocedure, patients obtained a median excess weight loss of 28%. Median body mass index decreased from 42.1 to 37.9 kg/m(2).
LIMITATIONS: Small number of patients.
CONCLUSION: Preliminary results of this transoral endoscopic restrictive implant system for the treatment of obesity showed successful placement in 12 of 13 patients. Procedural complications occurred in 3 patients. Weight loss was comparable to that of laparoscopic gastric band placement. Further long-term studies are under way.
OBJECTIVE: To evaluate the short-term safety and efficacy of an endoscopic restrictive implant procedure in the treatment of obesity.
DESIGN: Prospective, observational study.
SETTING: Tertiary-care referral hospital in The Netherlands.
PATIENTS: This study involved 13 patients with body mass indexes of between 40 and 50 kg/m(2) or between 35 and 40 kg/m(2) with obesity-related comorbidities.
INTERVENTION: A new transoral endoscopic restrictive implant procedure in the treatment of obesity.
MAIN OUTCOME MEASUREMENTS: Safety of the procedure, percentage of excess weight loss, change in body mass index.
RESULTS: In 1 patient, the procedure was abandoned after a gastric perforation related to stapler malfunctioning. In 2 patients, pneumoperitoneum was detected. This was desufflated with a percutaneous hollow needle in one patient and treated conservatively in the other. After these complications, technical adjustments were made in the procedure, and no subsequent procedural complications were seen. At 3 months postprocedure, patients obtained a median excess weight loss of 28%. Median body mass index decreased from 42.1 to 37.9 kg/m(2).
LIMITATIONS: Small number of patients.
CONCLUSION: Preliminary results of this transoral endoscopic restrictive implant system for the treatment of obesity showed successful placement in 12 of 13 patients. Procedural complications occurred in 3 patients. Weight loss was comparable to that of laparoscopic gastric band placement. Further long-term studies are under way.
Предметные рубрики MeSH
AdultAnesthesia, GeneralBody Mass IndexCardiaFemaleFollow-Up StudiesGastroplastyGastroscopyHumansMaleMiddle AgedObesity, MorbidPneumoperitoneumPostoperative CarePostoperative ComplicationsProspective StudiesProstheses and ImplantsQuality of LifeSurgical InstrumentsSurgical StaplingTreatment OutcomeWeight Loss