[Topography of changes in the mucosa of the gastro-duodenal region in chronic gastritis and peptic ulcer].

Topographic studies of 789 gastro- and duodenobiopsies obtained from 493 patients with chronic gastritis and peptic ulcer and from 37 individuals without gastro-duodenal pathology obtained various regions of the stomach and the duodenum were carried out. It was found out that investigation of only one piece of the tissue not in all cases reflected a histological state of the mucosa of the certain regions of the gastro-duodenal area. An isolated gastritis in the body of the stomach in patients with chronic gastritis was found to occur 3 times as seldom as in its distal region. The mucosa of the duodenum was affected almost equally often both in peptic ulcer of this organ and in chronic gastritis. In a number of patients the clinical picture diagnosed as chronic gastritis in reality turned out to be caused by morphological changes in the mucosa of the duodenum, but not of the stomach. At the same time, in a duodenal localization of ulcer not infrequently there were observed histological changes in the gastric mucosa aggravating the course of the main pathological process.