Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Buckland Genevieve, Agudo Antonio, Luján Leila, Jakszyn Paula, Bueno-de-Mesquita H Bas, Palli Domenico, Boeing Heiner, Carneiro Fátima, Krogh Vittorio, Sacerdote Carlotta, Tumino Rosario, Panico Salvatore, Nesi Gabriella, Manjer Jonas, Regnér Sara, Johansson Ingegerd, Stenling Roger, Sanchez María-José, Dorronsoro Miren, Barricarte Aurelio, Navarro Carmen, Quirós J Ramón, Allen Naomi E, Key Timothy J, Bingham Sheila, Kaaks Rudolf, Overvad Kim, Jensen Majken, Olsen Anja, Tjønneland Anne, Peeters Petra H M, Numans Mattijs E, Ocké Marga C, Clavel-Chapelon Françoise, Morois Sophie, Boutron-Ruault Marie-Christine, Trichopoulou Antonia, Lagiou Pagona, Trichopoulos Dimitrios, Lund Eiliv, Couto Elisabeth, Boffeta Paolo, Jenab Mazda, Riboli Elio, Romaguera Dora, Mouw Traci, González Carlos A
Аннотация
OBJECTIVE: We aimed to explore the association between adherence to a relative Mediterranean diet (rMED) and incident gastric adenocarcinoma (GC) within the European Prospective Investigation into Cancer and Nutrition study.
DESIGN: The study included 485,044 subjects (144,577 men) aged 35-70 y from 10 European countries. At recruitment, dietary and lifestyle information was collected. An 18-unit rMED score, incorporating 9 key components of the Mediterranean diet, was used to estimate rMED adherence. The association between rMED and GC with respect to anatomic location (cardia and noncardia) and histologic types (diffuse and intestinal) was investigated. A calibration study in a subsample was used to control for dietary measurement error.
RESULTS: After a mean follow-up of 8.9 y, 449 validated incident GC cases were identified and used in the analysis. After stratification by center and age and adjustment for recognized cancer risk factors, high compared with low rMED adherence was associated with a significant reduction in GC risk (hazard ratio: 0.67; 95% CI: 0.47, 0.94). A 1-unit increase in the rMED score was associated with a decreased risk of GC of 5% (95% CI: 0.91, 0.99). There was no evidence of heterogeneity between different anatomic locations or histologic types. The calibrated results showed similar trends (overall hazard ratio for GC: 0.93; 95% CI: 0.89, 0.99).
CONCLUSION: Greater adherence to an rMED is associated with a significant reduction in the risk of incident GC.