Journal of Crohn's & colitis · 2023
Results of the Eighth Scientific Workshop of ECCO: Pathophysiology and Risk Factors of Postoperative Crohn's Disease Recurrence after an Ileocolonic Resection.
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Rivière Pauline, Bislenghi Gabriele, Hammoudi Nassim, Verstockt Bram, Brown Steven, Oliveira-Cunha Melissa, Bemelman Willem, Pellino Gianluca, Kotze Paulo Gustavo, 8th Scientific Workshop of the European Crohn’s and Colitis Organisation, Ferrante Marc, Panis Yves
Аннотация
Postoperative recurrence [POR] after an ileocolonic resection with ileocolonic anastomosis is frequently encountered in patients with Crohn's disease. The 8th Scientific Workshop of ECCO reviewed the available evidence on the pathophysiology and risk factors for POR. In this paper, we discuss published data on the role of the microbiome, the mesentery, the immune system and the genetic background. In addition to investigating the causative mechanisms of POR, identification of risk factors is essential to tailor preventive strategies. Potential clinical, surgical and histological risk factors are presented along with their limitations. Emphasis is placed on unanswered research questions, guiding prevention of POR based on individual patient profiles.