Physiology of the human sphincter of Oddi.

During the last 25 years relevant data which contribute to the clarification of pancreatico-biliary sphincter function, have been derived from physiological and pharmacological studies, and from cinefluorographic and manometric observations in man. The human sphincter of Oddi appears to be a complex device, relatively independent of the duodenum and endowed with a primarily occluding action. Perendoscopic, pre- and post-operative sphincter of Oddi manometry has opened up new prospectives for a better definition of old concepts, such as biliary dyskinesia and post-cholecystectomy syndrome. In addition, manometric measurement may provide a more rational basis for sphincterotomy, and could allow endoscopists and surgeons to objectively evaluate the extent of sphincter splitting.