[The expression of cell adhesion molecule Syndecan-1 and E-candherin in laryngeal cancer].

OBJECTIVE

To observe Syndecan-1 and E-candherin expression and their relationship with clinico-pathologic factors in primary laryngeal squamous cell carcinoma(LSCC).

METHOD: Syndecan-1 and E-candherin proteins were determined with immunohistochemical technique.

RESULT: In invasive LSCC the expression of these two adhesion molecules were very similar. Both diminished with decreasing cell differentiation, lacked often in poorly differentiated tumors. And their expression were significantly correlated with each other.

CONCLUSION

Our results suggest that Syndecan-1 and E-candherin expression correlates significantly with the histological differentiation grade of the tumors and the tumors size. They may play important roles in the pathogensis and the development of LSCC.