American journal of surgery · 2016
The effect of time to sentinel lymph node biopsy on cutaneous melanoma survival.
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Fortes Cristina, Mastroeni Simona, Caggiati Alessio, Passarelli Francesca, Zappalà Alba, Capuano Maria, Bono Riccardo, Nudo Maurizio, Marino Claudia, Michelozzi Paola
Аннотация
BACKGROUND: Whether timing of sentinel lymph node biopsy (SLNB) in cutaneous melanoma improves survival is not yet clear. The aim of this study was to investigate if the timing of SLNB influences long-term melanoma mortality.
METHODS: A 10-year retrospective cohort study was conducted on 748 cutaneous melanoma patients who underwent excision of the SLN. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models.
RESULTS: After adjusting for sex, age, Breslow thickness, mitotic rate, ulceration, and histologic type, patients who underwent early SLNB (≤30 days) and resulted positive on final pathology had a 3 times decreased risk of melanoma mortality (hazard ratio = .29; 95%confidence interval = .11 to .77) in comparison to patients who underwent delayed SLNB (≥31 days) and resulted positive on final pathology.
CONCLUSIONS: Our findings suggest that early SLNB (≤30 days) improves melanoma survival.
METHODS: A 10-year retrospective cohort study was conducted on 748 cutaneous melanoma patients who underwent excision of the SLN. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models.
RESULTS: After adjusting for sex, age, Breslow thickness, mitotic rate, ulceration, and histologic type, patients who underwent early SLNB (≤30 days) and resulted positive on final pathology had a 3 times decreased risk of melanoma mortality (hazard ratio = .29; 95%confidence interval = .11 to .77) in comparison to patients who underwent delayed SLNB (≥31 days) and resulted positive on final pathology.
CONCLUSIONS: Our findings suggest that early SLNB (≤30 days) improves melanoma survival.
Предметные рубрики MeSH
AdultAgedCause of DeathCohort StudiesConfidence IntervalsDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMelanomaMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisProportional Hazards ModelsRetrospective StudiesSentinel Lymph NodeSentinel Lymph Node BiopsySkin NeoplasmsStatistics, NonparametricSurvival AnalysisTime FactorsTreatment OutcomeCutaneous Malignant Melanoma