Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2011
Hydrogen sulfide inhibits the spontaneous and oxytocin-induced contractility of human pregnant myometrium.
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Hu Rong, Lu Jianqiang, You Xingji, Zhu Xiaoyan, Hui Ning, Ni Xin
Аннотация
Hydrogen sulfide (H(2)S) is a novel endogenous gaseous signaling transmitter in mammalian tissues including smooth muscle tissues. We investigated the effect of sodium hydrosulfide (NaHS), a H(2)S donor, on the contractility of isolated human myometrium strips from term pregnant women who were undergoing labor. Cumulative effects of NaHS on spontaneous and oxytocin-induced contractility were evaluated by using isometric tension recordings. NaHS (0.1 μM-1 mM) concentration dependently inhibited spontaneous contractility of laboring myometrium, with a decrease in amplitude and frequency. NaHS (0.1 μM-1 mM) decreased the frequency but not the amplitude of oxytocin (1 μM)-induced contractions. NaHS-induced relaxation could be prevented by pretreatment with glibenclamide, an inhibitor of K(+)(ATP) channels. Thus, NaHS evokes relaxation of human pregnant myometrium, suggesting a possible role of H(2)S during human pregnancy.