European journal of obstetrics, gynecology, and reproductive biology · 2011
Correlation of thrombomodulin expression and occlusion of the uterine artery for the treatment of leiomyoma.
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Gong Jun, Xie Yan, Dou Fangfang, Kang Le, Cheng Zhongping
Аннотация
OBJECTIVES: To determine the difference in thrombomodulin expression in the myometrium and in myoma; and to understand the correlation of anticoagulation/fibrinolytic function and the mechanism of uterine artery occlusion in the treatment of leiomyoma.
STUDY DESIGN: Immunohistochemistry, western blotting and fluorescence quantitative polymerase chain reaction were used to investigate thrombomodulin protein expression and gene transcription in 15 female patients.
RESULTS: Thrombomodulin was mainly expressed in endotheliocytes in the two types of tissues. According to western blotting data, the relative expression of protein of the myometrium was 1.49 times higher than that of the myoma. This difference was significant (P < 0.01). The relative transcription of thrombomodulin mRNA was 1.28 times higher in myometrial tissue than in myomal tissue (P < 0.05).
CONCLUSIONS: Anticoagulation/fibrinolytic functions may be higher in the myometrium than in fibroids. This may be an important explanation for the mechanism of uterine artery occlusion.
STUDY DESIGN: Immunohistochemistry, western blotting and fluorescence quantitative polymerase chain reaction were used to investigate thrombomodulin protein expression and gene transcription in 15 female patients.
RESULTS: Thrombomodulin was mainly expressed in endotheliocytes in the two types of tissues. According to western blotting data, the relative expression of protein of the myometrium was 1.49 times higher than that of the myoma. This difference was significant (P < 0.01). The relative transcription of thrombomodulin mRNA was 1.28 times higher in myometrial tissue than in myomal tissue (P < 0.05).
CONCLUSIONS: Anticoagulation/fibrinolytic functions may be higher in the myometrium than in fibroids. This may be an important explanation for the mechanism of uterine artery occlusion.