Ginekologia polska · 2010
[Tumor necrosis factor in uterine leiomyomas at various stages of tumor growth].
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Wolańska Małgorzata, Taudul Ewelina, Bańkowska-Guszczyn Emilia, Kinalski Maciej
Аннотация
OBJECTIVES: The aim of the study was to evaluate the expression of tumor necrosis factors -alpha and beta (TNF), their receptor and content in human uterine leiomyomas at various stages of tumor growth.
MATERIAL AND METHODS: Studies were performed on human myometrium and uterine leiomyomas of various weights (small: less than 10 g and large: more than 100 g). Presence of both growth factors and their receptor was detected by Western Immunoblotting technique. The content of TNF-alpha was evaluated by immunoenzymatic method (ELISA).
RESULTS: Changes in the expression of tumor necrosis factors and their receptor and difference in content of TNF-alpha during the tumor growth were found.
CONCLUSIONS: Myometrium conversion into leiomyoma and an increase in its mass is accompanied by changes in the expression and contents TNF and TNF RI.
MATERIAL AND METHODS: Studies were performed on human myometrium and uterine leiomyomas of various weights (small: less than 10 g and large: more than 100 g). Presence of both growth factors and their receptor was detected by Western Immunoblotting technique. The content of TNF-alpha was evaluated by immunoenzymatic method (ELISA).
RESULTS: Changes in the expression of tumor necrosis factors and their receptor and difference in content of TNF-alpha during the tumor growth were found.
CONCLUSIONS: Myometrium conversion into leiomyoma and an increase in its mass is accompanied by changes in the expression and contents TNF and TNF RI.