Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion · 2009
[Anti-C. trachomatis IgG antibodies levels in serum to identify infertility caused by tubal damage].
Клиническое исследованиеАннотация на английскомПисьмо в редакциюНазвание и аннотация: Перевод пока не подготовлен
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Hernández-Trejo María, López-Hurtado Marcela, Arteaga-Troncoso Gabriel, Guerra-Infante Fernando M
Аннотация
OBJECTIVE: To identify the serologic titers of anti-Chlamydia trachomatis IgG (Ab) antibodies that could be used to differentiate tubal damage infertility from other causes of subfertility in a group of Mexican women.
MATERIAL AND METHODS: This was a prospective, longitudinal and analytical study of 147 women selected in a non-random way. The women were classified into three sub-groups: 1) infertile women with tubal occlusion detected by laparoscopy (n = 58); 2) infertile women with alternative causes of subfertility (n = 50), and 3) fertile women for the control group (n = 39). An assay of indirect immunofluorescence was performed on all infertile women (n = 108). The results obtained were compared with the laparoscopic and hormonal analyses carried out on the 108 infertile women. The statistical analysis included a model in ROC Curve and Logistical Regression.
RESULTS: The results showed that the titer 1:256 is able to differentiate fertile women from infertile women. Moreover, in the adjusted analysis, the titer 1:512 was able to identify infertile women with tubal occlusion (OR 2.6, CI 95% 1.24, 5.4), with a sensibility of 40% and a specificity of 90%. Positive and negative predictive values were 85% and 50%, respectively and the positive and negative likelihood ratios were 3.85 and 0.67, respectively. The pattern of the ROC curve confirmed a court value of 1:512, with an area under the curve of 62.2% (CI 95%: 53.4-72%).
CONCLUSION: A titer greater or equal to 1:512 of anti-C. trachomatis IgG antibodies is useful in the identification of tubal factor infertility.
MATERIAL AND METHODS: This was a prospective, longitudinal and analytical study of 147 women selected in a non-random way. The women were classified into three sub-groups: 1) infertile women with tubal occlusion detected by laparoscopy (n = 58); 2) infertile women with alternative causes of subfertility (n = 50), and 3) fertile women for the control group (n = 39). An assay of indirect immunofluorescence was performed on all infertile women (n = 108). The results obtained were compared with the laparoscopic and hormonal analyses carried out on the 108 infertile women. The statistical analysis included a model in ROC Curve and Logistical Regression.
RESULTS: The results showed that the titer 1:256 is able to differentiate fertile women from infertile women. Moreover, in the adjusted analysis, the titer 1:512 was able to identify infertile women with tubal occlusion (OR 2.6, CI 95% 1.24, 5.4), with a sensibility of 40% and a specificity of 90%. Positive and negative predictive values were 85% and 50%, respectively and the positive and negative likelihood ratios were 3.85 and 0.67, respectively. The pattern of the ROC curve confirmed a court value of 1:512, with an area under the curve of 62.2% (CI 95%: 53.4-72%).
CONCLUSION: A titer greater or equal to 1:512 of anti-C. trachomatis IgG antibodies is useful in the identification of tubal factor infertility.
Предметные рубрики MeSH
AdultAntibodies, BacterialChlamydia InfectionsChlamydia trachomatisFallopian Tube DiseasesFallopian Tube Patency TestsFemaleFluorescent Antibody Technique, IndirectHumansImmunoglobulin GInfertility, FemaleLaparoscopyPredictive Value of TestsProspective StudiesROC CurveSensitivity and SpecificitySeroepidemiologic StudiesYoung Adult