American journal of otolaryngology · 2005
Labyrinthitis secondary to experimental otitis media.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Trinidad Almudena, Ramírez-Camacho Rafael, García-Berrocal Jose Ramon, Verdaguer Jose María, Daza Rosa
Аннотация
PURPOSE: Analysis of labyrinthitis in a model of otitis media.
MATERIALS AND METHODS: Morphologic study in 20 Wistar rats in which otitis media was induced by transbullar inoculation of Pseudomonas aeruginosa with obstruction of the eustachian tube.
RESULTS: Seventy percent of rats showed vestibular signs. Histologic changes ranged from nonaffected labyrinths to suppurative labyrinthitis.
CONCLUSIONS: Dissemination of infection probably occurs through round window membrane. A thinner round window membrane typical of rodents would be the reason for a more severe clinical and morphologic picture in rats when compared to human beings.
MATERIALS AND METHODS: Morphologic study in 20 Wistar rats in which otitis media was induced by transbullar inoculation of Pseudomonas aeruginosa with obstruction of the eustachian tube.
RESULTS: Seventy percent of rats showed vestibular signs. Histologic changes ranged from nonaffected labyrinths to suppurative labyrinthitis.
CONCLUSIONS: Dissemination of infection probably occurs through round window membrane. A thinner round window membrane typical of rodents would be the reason for a more severe clinical and morphologic picture in rats when compared to human beings.