Frontiers in medicine · 2024
Accumulated subcutaneous fat in abdomen is associated with long COVID-19 symptoms among non-hospitalized patients: a prospective observational study.
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Li Tingxin, He Baoming, Liu Yuping, Wang Chen
Аннотация
INTRODUCTION: Long COVID-19 symptoms may have a variety of potential overlapping causes. In this study, we aimed to investigate the potential correlation between abdominal adipose tissue and long COVID-19 symptoms in non-hospitalized patients in China.
METHODS: This is a prospective observational study. 424 subjects, recovered from COVID-19 for 2-4 weeks, were enrolled and 408 subjects were finished the follow-up investigation at baseline, 8th week and 12th week. Physical measurements were collected. Kaplan-Meier analysis and cox regression analysis were carried out to assess the correlation.
RESULTS: A total of 72 subjects reported the long COVID-19 symptoms. The adjusted Kaplan-Meier analysis and Cox regression analysis revealed a significant correlation with accumulated subcutaneous fat (SFA ≥ 2.0 dm2) and the long COVID-19 symptoms (HR = 2.63, P < 0.001 for male, HR = 1.52, P = 0.048 for female). However, overweight and central obesity showed positive correlation only in women.
DISCUSSION: This study suggested that accumulated subcutaneous fat in abdomen (SFA ≥ 2.0 dm2) was an important positive factor associated with long COVID-19 symptoms among Chinese non-hospitalized patients. Large investigation and prospective studies are needed to validate the correlation in the future.
METHODS: This is a prospective observational study. 424 subjects, recovered from COVID-19 for 2-4 weeks, were enrolled and 408 subjects were finished the follow-up investigation at baseline, 8th week and 12th week. Physical measurements were collected. Kaplan-Meier analysis and cox regression analysis were carried out to assess the correlation.
RESULTS: A total of 72 subjects reported the long COVID-19 symptoms. The adjusted Kaplan-Meier analysis and Cox regression analysis revealed a significant correlation with accumulated subcutaneous fat (SFA ≥ 2.0 dm2) and the long COVID-19 symptoms (HR = 2.63, P < 0.001 for male, HR = 1.52, P = 0.048 for female). However, overweight and central obesity showed positive correlation only in women.
DISCUSSION: This study suggested that accumulated subcutaneous fat in abdomen (SFA ≥ 2.0 dm2) was an important positive factor associated with long COVID-19 symptoms among Chinese non-hospitalized patients. Large investigation and prospective studies are needed to validate the correlation in the future.