The Journal of laryngology and otology · 2019
The effect of intratympanic oxytocin treatment on rats exposed to acoustic trauma.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Akin Ocal F C, Kesici G G, Gurgen S G, Ocal R, Erbek S
Аннотация
OBJECTIVE: To investigate whether oxytocin can prevent ototoxicity related to acoustic trauma.
METHODS: Twenty-eight rats were divided into four groups: noise (group 1), control (group 2), noise plus oxytocin (group 3), and oxytocin (group 4). Intratympanic oxytocin was administered on days 1, 2, 4, 6, 8 and 10 in groups 3 and 4. Groups 1 and 3 were exposed to acoustic trauma. Distortion product otoacoustic emission and auditory brainstem response testing were performed in all groups.
RESULTS: In group 1, auditory brainstem response thresholds increased significantly after acoustic trauma. In group 3, auditory brainstem response thresholds increased significantly on day 1 after acoustic trauma, but there were no significant differences between thresholds at baseline and on the 7th and 21st days. In group 1, significant differences were observed between distortion product otoacoustic emission signal-to-noise ratios measured before and on days 1, 7 and 21 after acoustic trauma. In group 3, no significant differences were observed between the distortion product otoacoustic emission signal-to-noise ratios measured before and on days 7 and 21 after acoustic trauma.
CONCLUSION: Oxytocin had a therapeutic effect on rats exposed to acoustic trauma in this experiment.
METHODS: Twenty-eight rats were divided into four groups: noise (group 1), control (group 2), noise plus oxytocin (group 3), and oxytocin (group 4). Intratympanic oxytocin was administered on days 1, 2, 4, 6, 8 and 10 in groups 3 and 4. Groups 1 and 3 were exposed to acoustic trauma. Distortion product otoacoustic emission and auditory brainstem response testing were performed in all groups.
RESULTS: In group 1, auditory brainstem response thresholds increased significantly after acoustic trauma. In group 3, auditory brainstem response thresholds increased significantly on day 1 after acoustic trauma, but there were no significant differences between thresholds at baseline and on the 7th and 21st days. In group 1, significant differences were observed between distortion product otoacoustic emission signal-to-noise ratios measured before and on days 1, 7 and 21 after acoustic trauma. In group 3, no significant differences were observed between the distortion product otoacoustic emission signal-to-noise ratios measured before and on days 7 and 21 after acoustic trauma.
CONCLUSION: Oxytocin had a therapeutic effect on rats exposed to acoustic trauma in this experiment.
Предметные рубрики MeSH
AnimalsBiopsy, NeedleDisease Models, AnimalEvoked Potentials, Auditory, Brain StemHearing Loss, Noise-InducedImmunohistochemistryInjections, IntralesionalMaleOtoacoustic Emissions, SpontaneousOxytocinRandom AllocationRatsRats, Sprague-DawleyReference ValuesSignal-To-Noise RatioStatistics, NonparametricTreatment OutcomeTympanic Membrane