American journal of human genetics · 2014

Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.

Сравнительное исследованиеСтатьяResearch Support, N.I.H., IntramuralНазвание и аннотация: Перевод пока не подготовлен

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Skibola Christine F, Berndt Sonja I, Vijai Joseph, Conde Lucia, Wang Zhaoming, Yeager Meredith, de Bakker Paul I W, Birmann Brenda M, Vajdic Claire M, Foo Jia-Nee, Bracci Paige M, Vermeulen Roel C H, Slager Susan L, de Sanjose Silvia, Wang Sophia S, Linet Martha S, Salles Gilles, Lan Qing, Severi Gianluca, Hjalgrim Henrik, Lightfoot Tracy, Melbye Mads, Gu Jian, Ghesquières Hervé, Link Brian K, Morton Lindsay M, Holly Elizabeth A, Smith Alex, Tinker Lesley F, Teras Lauren R, Kricker Anne, Becker Nikolaus, Purdue Mark P, Spinelli John J, Zhang Yawei, Giles Graham G, Vineis Paolo, Monnereau Alain, Bertrand Kimberly A, Albanes Demetrius, Zeleniuch-Jacquotte Anne, Gabbas Attilio, Chung Charles C, Burdett Laurie, Hutchinson Amy, Lawrence Charles, Montalvan Rebecca, Liang Liming, Huang Jinyan, Ma Baoshan, Liu Jianjun, Adami Hans-Olov, Glimelius Bengt, Ye Yuanqing, Nowakowski Grzegorz S, Dogan Ahmet, Thompson Carrie A, Habermann Thomas M, Novak Anne J, Liebow Mark, Witzig Thomas E, Weiner George J, Schenk Maryjean, Hartge Patricia, De Roos Anneclaire J, Cozen Wendy, Zhi Degui, Akers Nicholas K, Riby Jacques, Smith Martyn T, Lacher Mortimer, Villano Danylo J, Maria Ann, Roman Eve, Kane Eleanor, Jackson Rebecca D, North Kari E, Diver W Ryan, Turner Jenny, Armstrong Bruce K, Benavente Yolanda, Boffetta Paolo, Brennan Paul, Foretova Lenka, Maynadie Marc, Staines Anthony, McKay James, Brooks-Wilson Angela R, Zheng Tongzhang, Holford Theodore R, Chamosa Saioa, Kaaks Rudolph, Kelly Rachel S, Ohlsson Bodil, Travis Ruth C, Weiderpass Elisabete, Clavel Jacqueline, Giovannucci Edward, Kraft Peter, Virtamo Jarmo, Mazza Patrizio, Cocco Pierluigi, Ennas Maria Grazia, Chiu Brian C H, Fraumeni Joseph F, Nieters Alexandra, Offit Kenneth, Wu Xifeng, Cerhan James R, Smedby Karin E, Chanock Stephen J, Rothman Nathaniel

Аннотация

Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10(-67) to 2.67 × 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [OR(per-allele)] = 1.44; p = 4.59 × 10(-16)) and rs3130437 in HLA class I (OR(per-allele) = 1.23; p = 8.23 × 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.

Предметные рубрики MeSH

Alleles Biomarkers, Tumor Case-Control Studies Chromosomes, Human Genetic Predisposition to Disease Genome-Wide Association Study HLA Antigens Haplotypes Humans Lymphoma, Follicular Polymorphism, Single Nucleotide

Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.

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Аннотация

Предметные рубрики MeSH