Journal of the American Academy of Dermatology · 1993
Home UV phototherapy of early mycosis fungoides: long-term follow-up observations in thirty-one patients.
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Resnik K S, Vonderheid E C
Аннотация
BACKGROUND: In 1982 we reported our preliminary observations on the use of home UV phototherapy for patch and early plaque phase mycosis fungoides (MF).
OBJECTIVE: Our purpose was to present follow-up data of the original 31 patients, covering an interval of up to 15 years.
METHODS: All patients used a commercially available UV phototherapy unit that contained four Westinghouse FS40 fluorescent lamps for daily exposures of their non-sun-exposed skin regions.
RESULTS: A complete clinical and histologic response to home phototherapy occurred in 23 patients (74%) with a maximum duration of the response from 5 months to more than 15 years (median 51 months). After maintenance phototherapy was discontinued, seven patients (23%) had a sustained disease-free interval lasting more than 58 months (median > 90 months). This indicates that cure may have been achieved in a minority of patients. Phototherapy was well tolerated without evidence of significant photodamage or photocarcinogenicity.
CONCLUSION: These observations indicate that home phototherapy may be a therapeutic option for treatment of selected patients with early MF.
OBJECTIVE: Our purpose was to present follow-up data of the original 31 patients, covering an interval of up to 15 years.
METHODS: All patients used a commercially available UV phototherapy unit that contained four Westinghouse FS40 fluorescent lamps for daily exposures of their non-sun-exposed skin regions.
RESULTS: A complete clinical and histologic response to home phototherapy occurred in 23 patients (74%) with a maximum duration of the response from 5 months to more than 15 years (median 51 months). After maintenance phototherapy was discontinued, seven patients (23%) had a sustained disease-free interval lasting more than 58 months (median > 90 months). This indicates that cure may have been achieved in a minority of patients. Phototherapy was well tolerated without evidence of significant photodamage or photocarcinogenicity.
CONCLUSION: These observations indicate that home phototherapy may be a therapeutic option for treatment of selected patients with early MF.