Cancer · 1992
Soluble interleukin-2 receptor serum levels in mycosis fungoides. Correlation with clinical stage.
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Szeimies R M, Rueff F, Kaudewitz P
Аннотация
BACKGROUND: In a variety of non-Hodgkin lymphomas, a correlation between soluble interleukin-2 receptor levels (sIL-2R) and clinical stage is demonstrable. In mycosis fungoides (MF), two findings raise the question as to a similar correlation: (1) a proportion of tumor cells express IL-2 receptor and (2) sIL-2R is detectable in serum.
METHODS: sIL-2R were measured in patients with MF (n = 88) and atopic dermatitis (AD) (n = 14) by the enzyme immunoassay technique. Patients with AD served as controls. Cases of MF were classified according to the TNM staging classification.
RESULTS: Sera of patients with MF with stages III, IVa, and IVb showed significantly higher values than those of stage I or II and controls.
CONCLUSIONS: Although a close and significant correlation was found between sIL-2R levels and stage of disease in MF, it is still not clear whether elevated sIL-2R levels reflect disease activity or T-cell activation due to concomitant immunologic processes.
METHODS: sIL-2R were measured in patients with MF (n = 88) and atopic dermatitis (AD) (n = 14) by the enzyme immunoassay technique. Patients with AD served as controls. Cases of MF were classified according to the TNM staging classification.
RESULTS: Sera of patients with MF with stages III, IVa, and IVb showed significantly higher values than those of stage I or II and controls.
CONCLUSIONS: Although a close and significant correlation was found between sIL-2R levels and stage of disease in MF, it is still not clear whether elevated sIL-2R levels reflect disease activity or T-cell activation due to concomitant immunologic processes.