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DOI 10.1016/s1535-6108(03)00028-x

Медицинская библиотека · Cancer cell · 2003

The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma.

Rosenwald Andreas, Wright George, Wiestner Adrian, Chan Wing C, Connors Joseph M, Campo Elias, Gascoyne Randy D, Grogan Thomas M, Muller-Hermelink H Konrad, Smeland Erlend B, Chiorazzi Michael, Giltnane Jena M, Hurt Elaine M, Zhao Hong, Averett Lauren, Henrickson Sarah, Yang Liming, Powell John, Wilson Wyndham H, Jaffe Elaine S, Simon Richard, Klausner Richard D, Montserrat Emilio, Bosch Francesc, Greiner Timothy C, Weisenburger Dennis D, Sanger Warren G, Dave Bhavana J, Lynch James C, Vose Julie, Armitage James O, Fisher Richard I, Miller Thomas P, LeBlanc Michael, Ott German, Kvaloy Stein, Holte Harald, Delabie Jan, Staudt Louis M

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Аннотация

We used gene expression profiling to establish a molecular diagnosis of mantle cell lymphoma (MCL), to elucidate its pathogenesis, and to predict the length of survival of these patients. An MCL gene expression signature defined a large subset of MCLs that expressed cyclin D1 and a novel subset that lacked cyclin D1 expression. A precise measurement of tumor cell proliferation, provided by the expression of proliferation signature genes, identified patient subsets that differed by more than 5 years in median survival. Differences in cyclin D1 mRNA abundance synergized with INK4a/ARF locus deletions to dictate tumor proliferation rate and survival. We propose a quantitative model of the aberrant cell cycle regulation in MCL that provides a rationale for the design of cell cycle inhibitor therapy in this malignancy.

Для цитирования: Rosenwald Andreas, Wright George, Wiestner Adrian, Chan Wing C, Connors Joseph M, Campo Elias, Gascoyne Randy D, Grogan Thomas M, Muller-Hermelink H Konrad, Smeland Erlend B, Chiorazzi Michael, Giltnane Jena M, Hurt Elaine M, Zhao Hong, Averett Lauren, Henrickson Sarah, Yang Liming, Powell John, Wilson Wyndham H, Jaffe Elaine S, Simon Richard, Klausner Richard D, Montserrat Emilio, Bosch Francesc, Greiner Timothy C, Weisenburger Dennis D, Sanger Warren G, Dave Bhavana J, Lynch James C, Vose Julie, Armitage James O, Fisher Richard I, Miller Thomas P, LeBlanc Michael, Ott German, Kvaloy Stein, Holte Harald, Delabie Jan, Staudt Louis M. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma.. Cancer cell. 2003. DOI: 10.1016/s1535-6108(03)00028-x.

Предметные рубрики MeSH

ADP-Ribosylation FactorsAdultAgedAged, 80 and overAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsCyclin D1Cyclin-Dependent Kinase Inhibitor p16DNA-Binding ProteinsFemaleGene Expression ProfilingGenes, NeoplasmHumansLymphoma, Mantle-CellMaleMiddle AgedNeoplasm ProteinsPrognosisProtein Serine-Threonine KinasesRNA, MessengerRNA, NeoplasmReverse Transcriptase Polymerase Chain ReactionSurvival RateTumor Suppressor Protein p53Tumor Suppressor ProteinsUntranslated Regions
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