Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA · 2001
Expression of cyclin D1 in small cell lymphoma and its clinical implications.
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Zhou Xin-Hua, Zhao Tong, Zhu Mei-Gang, Liu Zhen-Xi, Yang Lei
Аннотация
OBJECTIVE: To observe the expression of cyclin D1 and explore its clinical significance in small cell lymphoma. METHODS: Immunohistochemical method was used to detect the expression of CD20, CD45RO and cyclin D1 in 31 formalin- fixed and paraffin-embedded tissue samples of human small cell lymphomas. RESULTS: Twenty-eight cases were categorized into B cell lymphoma and 3 into T cell lymphoma. Only 5 cases of B cell lymphoma had cyclin D1 expression (17.86%) that did not significantly differ between nodal and extranodal lymphomas (P>0.05), indicating the presence of mantle cell lymphoma. CONCLUSION: The overexpression of cyclin D1 is a highly characteristic and specific indicator that discriminates mantle cell lymphoma from other small cell lymphomas, and this protein may offer critial guidance for therapeutic protocol and prognostic estimation.