Cancer management and research · 2026
Six-Transmembrane Epithelial Antigen of the Prostate 1 Promotes HCC Proliferation and Metastasis in vitro and in vivo via the Wnt/β-Catenin Signaling Pathway.
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Liu Haichao, Gao Jie, Liu Xudong, Guo Wenzhi, Zhang Shuijun
Аннотация
OBJECTIVE: To investigate the role and underlying mechanism of Six-Transmembrane Epithelial Antigen of the Prostate 1 (STEAP1) in Hepatocellular carcinoma (HCC) progression, and to validate its potential as a therapeutic target.
MATERIALS AND METHODS: In this study, STEAP1-knockdown models were used to evaluate cell proliferation, invasion and migration. RNA sequencing (RNA-seq) were performed to explore downstream mechanisms. Subcutaneous Xenograft Model in nude mice was used to investigate the role of STEAP1 in the proliferation of HCC in vivo.
RESULTS: STEAP1 knockdown significantly inhibited HCC cell proliferation, invasion, and migration, downregulated the expression of EMT-related proteins, and suppressed activation of the Wnt signaling pathway. In vivo, STEAP1 silencing effectively reduced the growth of subcutaneous tumors in nude mice.
CONCLUSION: STEAP1 promotes HCC growth and metastasis by activating the Wnt/β-catenin signaling pathway, and may serve as a promising therapeutic target for HCC.
MATERIALS AND METHODS: In this study, STEAP1-knockdown models were used to evaluate cell proliferation, invasion and migration. RNA sequencing (RNA-seq) were performed to explore downstream mechanisms. Subcutaneous Xenograft Model in nude mice was used to investigate the role of STEAP1 in the proliferation of HCC in vivo.
RESULTS: STEAP1 knockdown significantly inhibited HCC cell proliferation, invasion, and migration, downregulated the expression of EMT-related proteins, and suppressed activation of the Wnt signaling pathway. In vivo, STEAP1 silencing effectively reduced the growth of subcutaneous tumors in nude mice.
CONCLUSION: STEAP1 promotes HCC growth and metastasis by activating the Wnt/β-catenin signaling pathway, and may serve as a promising therapeutic target for HCC.