Nevoid Hyperkeratosis of the Nipple and Areola: A Case Report.

We present a case of nevoid hyperkeratosis of the nipple and areola (NHNA) with emphasis on its clinical, dermoscopic, and histopathological features and the diagnostic challenges it poses. NHNA is a rare, generally benign dermatologic condition characterized by verrucous, hyperpigmented lesions of the nipple-areola complex. We report the case of a 21-year-old woman presenting with bilateral, symmetrical areolar thickening of progressive onset and no associated symptoms. A clinical diagnosis was made, and 20% urea treatment was prescribed, with no clinical improvement. One year later, due to lesion progression, a skin biopsy was performed to confirm the diagnosis histopathologically; 0.05% topical tretinoin was initiated, but the patient was lost to follow-up. This case highlights the importance of differential diagnosis and long-term follow-up in uncommon dermatoses of the nipple-areola complex.