Toxicology research · 2024
Protective effects of quercetin against tongue injury and oxidative stress triggered by irinotecan: a histopathological, biochemical and molecular study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Faruk Eman Mohamed, Ibrahim Fatma, Hassan Mahmoud M, Kamal Kamal M, Hassan Dina Allam Abdelmaksoud, Awwad Ayat Abu-Elnasr, Taha Neama Mahmoud, Hablas Mohamed Ghazy Attia, Zaazaa Ahmed Mohammed, Ibrahim Mai Hassan
Аннотация
INTRODUCTION: About 80% of patients receiving chemotherapeutics suffer from side effects related to the gastrointestinal tract. Irinotecan (CPT-11) is a chemotherapeutic agent usually used in treating solid tumors. Quercetin (QRT), a bioflavonoid, is an antioxidant and scavenger reactive oxygen species scavenger.
OBJECTIVE: The current study explored the possible protective effects of QRT against mucosal tongue injury caused by CPT-11.
METHODS: The study included four equal groups: group 1/control, group 2/QRT, group 3/CPT-11, and group 4/CPT-11 + QRT.
RESULTS: CPT-11-induced tongue injury in the form of non-healed ulcers, absent lingual papillae, mononuclear cells infiltration, marked deposition of collagen fibers, and overexpression of CD86 and tumor necrosis factor- α (TNF-α). The increased malondialdehyde levels, decreased superoxide dismutase and total antioxidant capacity revealed that there was an oxidative stress. Also, there was a decreased countenance of Ki-67 and Bcl-2 and an increased countenance of NF-κB. The QRT-treated group showed complete ulcer healing, with histological features almost like the control group, along with minimal collagen fiber deposition, decreased reactivity to CD86 and TNF-α and improvement of oxidative stress status and the molecular study results as well.
CONCLUSION: QRT possess protective properties against CPT-11-triggered tongue injury.
OBJECTIVE: The current study explored the possible protective effects of QRT against mucosal tongue injury caused by CPT-11.
METHODS: The study included four equal groups: group 1/control, group 2/QRT, group 3/CPT-11, and group 4/CPT-11 + QRT.
RESULTS: CPT-11-induced tongue injury in the form of non-healed ulcers, absent lingual papillae, mononuclear cells infiltration, marked deposition of collagen fibers, and overexpression of CD86 and tumor necrosis factor- α (TNF-α). The increased malondialdehyde levels, decreased superoxide dismutase and total antioxidant capacity revealed that there was an oxidative stress. Also, there was a decreased countenance of Ki-67 and Bcl-2 and an increased countenance of NF-κB. The QRT-treated group showed complete ulcer healing, with histological features almost like the control group, along with minimal collagen fiber deposition, decreased reactivity to CD86 and TNF-α and improvement of oxidative stress status and the molecular study results as well.
CONCLUSION: QRT possess protective properties against CPT-11-triggered tongue injury.