Zhurnal mikrobiologii, epidemiologii i immunobiologii · 2012
[Dynamics of microsymbiocenoses of upper respiratory tract in normal state and in pathology].
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Soboleva Iu V, Usviatsov B Ia, Khlopko Iu A, Bukharin O V
Аннотация
AIM: Study of features of interaction of bacteria in microsymbiocenoses of upper respiratory tract in dynamics in individuals with various state of health: healthy individuals, individuals after tonsillitis and bacteria carriers.
MATERIALS AND METHODS: Modification of pathogenicity factors (hemolytic, lecitovitellase, lysozyme and anti-lysozyme activity) in intermicrobial interactions of 226 strains of microorganisms isolated during quintuple analysis of upper respiratory tract biocenoses of examined individuals was studied. A hierarchical structure of each microbiocenosis was built based on the data obtained, and its temporal dynamics evaluated.
RESULTS: Microbial composition of mucous membrane of tonsils was more constant independent of state of health when compared with the nasal cavity. Normoflora that does not influence expression of pathogenicity factors and symbiont persistence was predominate and persisted for a long period in healthy individuals and bacteria carriers, whereas in individuals after tonsillitis opportunistic strains with a high communicative activity (leaders) that increase symbiont pathogenicity persisted for a long time.
CONCLUSION: The revealed differences in biocenoses dynamics of 2 biotopes of upper respiratory tract in healthy individuals, bacteria carriers and individuals after tonsillitis may be used to forecast stable health and development of dysbiotic disorders.
MATERIALS AND METHODS: Modification of pathogenicity factors (hemolytic, lecitovitellase, lysozyme and anti-lysozyme activity) in intermicrobial interactions of 226 strains of microorganisms isolated during quintuple analysis of upper respiratory tract biocenoses of examined individuals was studied. A hierarchical structure of each microbiocenosis was built based on the data obtained, and its temporal dynamics evaluated.
RESULTS: Microbial composition of mucous membrane of tonsils was more constant independent of state of health when compared with the nasal cavity. Normoflora that does not influence expression of pathogenicity factors and symbiont persistence was predominate and persisted for a long period in healthy individuals and bacteria carriers, whereas in individuals after tonsillitis opportunistic strains with a high communicative activity (leaders) that increase symbiont pathogenicity persisted for a long time.
CONCLUSION: The revealed differences in biocenoses dynamics of 2 biotopes of upper respiratory tract in healthy individuals, bacteria carriers and individuals after tonsillitis may be used to forecast stable health and development of dysbiotic disorders.