Journal of the science of food and agriculture · 2026
Marigold flavonoids coordinate emulsion stabilization, epithelial transport and gut microbiota modulation to enhance intestinal lutein absorption.
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Wang Sitong, Xu Zhiyue, Li Yingxi, Huang Tianyi, Shi Renli, Sang Yaxin, Yu Wenlong, Wang Xianghong
Аннотация
BACKGROUND: Flavonoids naturally coexisting with lutein in marigold (Tagetes erecta L.) extracts have been suggested to influence carotenoid bioavailability; however, their coordinated roles in intestinal lutein absorption remain insufficiently understood. This study systematically explored the synergistic effects of six major marigold flavonoids on lutein absorption via a multilevel strategy integrating emulsion behavior, intestinal epithelial transport and gut microbiota modulation.
RESULTS: In vitro, flavonoids stabilized lutein-containing mixed emulsion, reduced particle size, increased ζ-potential and enhanced bioaccessibility. In Caco-2 cells, they promoted lutein uptake and trans-epithelial transport, upregulated key transporters (SR-BI, CD36, NPC1L1) and reinforced tight junction integrity. In vivo, their co-administration increased lutein accumulation in eyes, liver and intestinal tissues, enhanced carotenoid cleavage enzyme activities, and reshaped gut microbiota and short-chain fatty acid production.
CONCLUSION: Marigold flavonoids facilitate intestinal lutein absorption via multiple pathways, improving the in vivo bioavailability of lutein. This study clarifies the synergistic interaction between marigold flavonoids and lutein, providing a theoretical basis for the rational application of marigold-derived flavonoids and carotenoids in functional food development. © 2026 Society of Chemical Industry.
RESULTS: In vitro, flavonoids stabilized lutein-containing mixed emulsion, reduced particle size, increased ζ-potential and enhanced bioaccessibility. In Caco-2 cells, they promoted lutein uptake and trans-epithelial transport, upregulated key transporters (SR-BI, CD36, NPC1L1) and reinforced tight junction integrity. In vivo, their co-administration increased lutein accumulation in eyes, liver and intestinal tissues, enhanced carotenoid cleavage enzyme activities, and reshaped gut microbiota and short-chain fatty acid production.
CONCLUSION: Marigold flavonoids facilitate intestinal lutein absorption via multiple pathways, improving the in vivo bioavailability of lutein. This study clarifies the synergistic interaction between marigold flavonoids and lutein, providing a theoretical basis for the rational application of marigold-derived flavonoids and carotenoids in functional food development. © 2026 Society of Chemical Industry.