The Journal of thoracic and cardiovascular surgery · 2026
A novel ex vivo model of unbalanced common atrioventricular valve: Insights into biomechanics and hemodynamics during single ventricle palliation.
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Munshi Sayar Kumar, Huber Jay Andrew, Sharir Amit, Ono Yoshikazu, Choi Perry Seo, Reed Alexander Keith, Kaiser Alexander D, Ma Michael Raosen
Аннотация
OBJECTIVES: To investigate biomechanics and failure mechanisms of unbalanced right-dominant common atrioventricular valves (CAVVs) across stages of single-ventricle palliation (SVP).
METHODS: A patient-specific adjustable valve testing mount was developed, and size-matched porcine tricuspid and mitral valves were combined to construct CAVVs (n = 5). Valves were tested in a heart simulator under hemodynamic conditions replicating Norwood, Glenn, and Fontan physiologies. Papillary muscles were displaced vertically and horizontally to simulate chordal prolapse, shortening, and ventricular dilatation. Strain sensors configured as neochordae quantified leaflet force profiles.
RESULTS: Bridging leaflets experienced greater peak and mean forces than mural leaflets (P < .05), correlating with larger leaflet surface area. Regurgitant fraction (RF) increased with all geometric perturbations (P < .001), with greater rate of increase during chordal prolapse than shortening. Forces were greater in 5-mm chordal prolapse compared with baseline. Forces decreased in 5-mm chordal shortening and ventricular dilatations as RF increased. Peak leaflet forces and average yank were greatest under Norwood conditions (P < .05), whereas mean forces were greatest during Fontan physiology (P < .01). Although RF increased with geometric changes at all SVP stages, the relative increase over baseline was greatest during Norwood (P < .05).
CONCLUSIONS: Stage-dependent loading conditions and ventricular geometry critically determine CAVV biomechanics and failure during SVP. Glenn offloading reduces peak leaflet forces and improves valve performance, whereas Fontan afterload increases mean leaflet stress, potentially accelerating long-term failure. Ventricular geometric perturbations exert the greatest adverse effect during Norwood, conferring the greatest risk of valve dysfunction.
METHODS: A patient-specific adjustable valve testing mount was developed, and size-matched porcine tricuspid and mitral valves were combined to construct CAVVs (n = 5). Valves were tested in a heart simulator under hemodynamic conditions replicating Norwood, Glenn, and Fontan physiologies. Papillary muscles were displaced vertically and horizontally to simulate chordal prolapse, shortening, and ventricular dilatation. Strain sensors configured as neochordae quantified leaflet force profiles.
RESULTS: Bridging leaflets experienced greater peak and mean forces than mural leaflets (P < .05), correlating with larger leaflet surface area. Regurgitant fraction (RF) increased with all geometric perturbations (P < .001), with greater rate of increase during chordal prolapse than shortening. Forces were greater in 5-mm chordal prolapse compared with baseline. Forces decreased in 5-mm chordal shortening and ventricular dilatations as RF increased. Peak leaflet forces and average yank were greatest under Norwood conditions (P < .05), whereas mean forces were greatest during Fontan physiology (P < .01). Although RF increased with geometric changes at all SVP stages, the relative increase over baseline was greatest during Norwood (P < .05).
CONCLUSIONS: Stage-dependent loading conditions and ventricular geometry critically determine CAVV biomechanics and failure during SVP. Glenn offloading reduces peak leaflet forces and improves valve performance, whereas Fontan afterload increases mean leaflet stress, potentially accelerating long-term failure. Ventricular geometric perturbations exert the greatest adverse effect during Norwood, conferring the greatest risk of valve dysfunction.