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DOI 10.1016/j.ijbiomac.2025.143280

Медицинская библиотека · International journal of biological macromolecules · 2025

Modification of coconut insoluble dietary fiber by enzymatic extraction and high-pressure homogenization: physicochemical property changes and inhibitory effects on pancreatic lipase activity.

Gao Xia, Yi Xiangzhou, Pei Zhisheng, Xia Guanghua, Zhao Zifang, Shen Xuanri

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Аннотация

In this study, coconut insoluble dietary fiber (CIDF) was modified by high-pressure homogenization (HPH), and the physicochemical properties and pancreatic lipase (PL) inhibitory activity were investigated. HPH diminished the particle size of CIDF (859.90 nm to 232.80 nm) and increased the total surface area and gap ratio. HPH enhanced the water and oil holding capacities of CIDF from 6.01 to 10.33 g/g and from 6.52 to 9.87 g/g, respectively. CIDF markedly inhibited PL activity by up to 72.51 % (p < 0.05), with the inhibition rate of PL was significantly higher in HPH-modified CIDF than in unmodified CIDF. The exposure of CIDF's hydroxyl groups due to the HPH treatment directly affected the degree of binding of CIDF to PL. CIDF reduces PL activity through hydrogen bonding and hydrophobic interactions with its aromatic amino acid residues.

Для цитирования: Gao Xia, Yi Xiangzhou, Pei Zhisheng, Xia Guanghua, Zhao Zifang, Shen Xuanri. Modification of coconut insoluble dietary fiber by enzymatic extraction and high-pressure homogenization: physicochemical property changes and inhibitory effects on pancreatic lipase activity.. International journal of biological macromolecules. 2025. DOI: 10.1016/j.ijbiomac.2025.143280.

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