Journal of magnetic resonance imaging : JMRI · 2025
Quantification of the Proton Density Fat Fraction and Iron Content: A Comparative Study Between 3.0 T and 5.0 T MRI.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Li Yali, Jin Dan, Liu Suwei, Jiang Chenyu, Ni Ming, Feng Limin, Zhang Yan, Yang Yuxin, Zhou Guangjin, Xu Jiajia, He Shipei, Zhou Liqiang, Yuan Huishu
Аннотация
BACKGROUND: Proton density fat fraction (PDFF) and R2* are noninvasive MRI biomarkers for quantifying fat and iron in abdominal organs. While 3.0 T MRI is widely used clinically, 5.0 T may offer improved accuracy and reliability. With the increasing availability of 5.0 T, assessing its feasibility and utility for quantifying PDFF and R2* in abdominal organs is needed.
PURPOSE: To determine the agreement of the PDFF and R2* in the liver, pancreas, kidney, and paraspinal muscle at 2 different field strengths.
STUDY TYPE: Prospective.
POPULATION: A total of 127 participants, including 60 healthy volunteers and 67 with metabolic dysfunction-associated steatotic liver disease (100 women and 27 men, 52 ± 9 years old).
FIELD STRENGTH/SEQUENCE: 3.0 T and 5.0 T; Chemical shift-encoded multi-echo gradient echo sequence.
ASSESSMENT: PDFF and R2* values in the liver, pancreas, kidney, and paraspinal muscle were measured by three observers to evaluate the interobserver and interfield agreement using two 3.0 T scanners (scanner 1 and scanner 2) and one 5.0 T scanner.
STATISTICAL TESTS: Linear regression, Bland-Altman analyses, and intraclass correlation coefficients (ICCs). The p-value < 0.05 indicated statistically significant.
RESULTS: PDFF and R2* at 5.0 T were strongly correlated with those at two 3.0 T scanners for all organs (R 2 = 0.905-0.998 for PDFF; 0.831-0.991 for R2*), indicating high interfield ICCs (0.892-0.993 for PDFF; 0.910-0.981 for R2*). Comparisons between 5.0 T and two 3.0 T scanners showed good interfield agreement for PDFF (mean bias, -0.57% to 0.03%) while a higher bias for R2* (mean bias, -16.53 to -2.64 s-1, 95% LoA, -34.28 to 1.21 s-1) at 5.0 T compared to the comparison between 3T scanners.
DATA CONCLUSION: 5.0 T revealed high interfield agreement between the PDFF and R2* with 3.0 T, which could provide reliable quantification of fat and iron contents in abdominal organs.
EVIDENCE LEVEL: 2.
TECHNICAL EFFICACY: Stage 2.
PURPOSE: To determine the agreement of the PDFF and R2* in the liver, pancreas, kidney, and paraspinal muscle at 2 different field strengths.
STUDY TYPE: Prospective.
POPULATION: A total of 127 participants, including 60 healthy volunteers and 67 with metabolic dysfunction-associated steatotic liver disease (100 women and 27 men, 52 ± 9 years old).
FIELD STRENGTH/SEQUENCE: 3.0 T and 5.0 T; Chemical shift-encoded multi-echo gradient echo sequence.
ASSESSMENT: PDFF and R2* values in the liver, pancreas, kidney, and paraspinal muscle were measured by three observers to evaluate the interobserver and interfield agreement using two 3.0 T scanners (scanner 1 and scanner 2) and one 5.0 T scanner.
STATISTICAL TESTS: Linear regression, Bland-Altman analyses, and intraclass correlation coefficients (ICCs). The p-value < 0.05 indicated statistically significant.
RESULTS: PDFF and R2* at 5.0 T were strongly correlated with those at two 3.0 T scanners for all organs (R 2 = 0.905-0.998 for PDFF; 0.831-0.991 for R2*), indicating high interfield ICCs (0.892-0.993 for PDFF; 0.910-0.981 for R2*). Comparisons between 5.0 T and two 3.0 T scanners showed good interfield agreement for PDFF (mean bias, -0.57% to 0.03%) while a higher bias for R2* (mean bias, -16.53 to -2.64 s-1, 95% LoA, -34.28 to 1.21 s-1) at 5.0 T compared to the comparison between 3T scanners.
DATA CONCLUSION: 5.0 T revealed high interfield agreement between the PDFF and R2* with 3.0 T, which could provide reliable quantification of fat and iron contents in abdominal organs.
EVIDENCE LEVEL: 2.
TECHNICAL EFFICACY: Stage 2.