Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie · 2018
Transdifferentiations and heterogeneity in the stromal niches of uterine leiomyomas.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
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Rusu Mugurel Constantin, Pop Florinel, Hostiuc Sorin, Manta Livia, Măru Nicoleta, Grigoriu Mihai
Аннотация
Uterine leiomyomas, also known as uterine fibroids (UFs), are benign smooth muscle cells tumors, the most frequent tumors in women. Even though UFs are monoclonal tumors, they contain a heterogeneous and versatile cells population. There are scarce proofs about the processes of transdifferentiation that might occur in UFs, modify the tumor microenvironment and support blood and lymph vessels formation. The stromal niches of the UFs harbor cells with angiogenic∕lymphangiogenic, as well as with vasculogenic∕lymphvasculogenic potential, which belong to a phenotypic continuum between the endothelial and mesenchymal lineages. Within these niches, the expressions of CD44 and podoplanin were less investigated and regarded as markers of such processes of transdifferentiation.