Frontiers in pharmacology · 2026
Protection against cisplatin-induced acute kidney injury by hellgrammite extract: insights from comprehensive metabolomics.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lin Kexin, Lu Guangling, Liu Rui, He Yanmei, Yuan Xiaoyan, Li Xiaofei, Wu Yiqin, Zhang Jianyong, Cao Chengquan
Аннотация
BACKGROUND: Cisplatin (CP), a highly potent antineoplastic agent, is severely limited in clinical use by dose-limiting toxicities, particularly acute kidney injury (AKI). The hellgrammite (Hel), a kind of rare edible and medicinal insect, is known in Traditional Chinese Medicine (TCM) for its ability to tonify the qi and kidneys. However, its potential to ameliorate CP-induced AKI remains unexplored.
METHODS: We first evaluated the nutritional profile of Hel using high-performance liquid chromatography (HPLC) for amino acid composition analysis. Subsequently, a mouse model of CP-induced AKI was treated with different doses of Hel by gavage, then traditional pharmacology, and metabolomics were used to elucidate the effects and mechanism of Hel on CP-induced AKI mice.
RESULTS: Hel effectively ameliorated CP-induced alterations in biochemical indicators and alleviated kidney pathological changes. Hel administration rectified the kidney metabolic disturbances induced by CP, involving alterations in 38 differential metabolites associated with glycerophospholipid metabolism, purine metabolism, nicotinate and nicotinamide metabolism, and thiamine metabolism.
DISCUSSION: Hel confers renoprotection by reversing metabolic disorders in CP-induced AKI, revealing actionable targets for AKI intervention.
METHODS: We first evaluated the nutritional profile of Hel using high-performance liquid chromatography (HPLC) for amino acid composition analysis. Subsequently, a mouse model of CP-induced AKI was treated with different doses of Hel by gavage, then traditional pharmacology, and metabolomics were used to elucidate the effects and mechanism of Hel on CP-induced AKI mice.
RESULTS: Hel effectively ameliorated CP-induced alterations in biochemical indicators and alleviated kidney pathological changes. Hel administration rectified the kidney metabolic disturbances induced by CP, involving alterations in 38 differential metabolites associated with glycerophospholipid metabolism, purine metabolism, nicotinate and nicotinamide metabolism, and thiamine metabolism.
DISCUSSION: Hel confers renoprotection by reversing metabolic disorders in CP-induced AKI, revealing actionable targets for AKI intervention.