Archives of gynecology and obstetrics · 2025
Clinical factors that influence chorionic villus sampling sample size.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Alamri Lamia, Ludwigson Abigail, Kaizer Laura K, Hamilton Simone, Haag Mary, Sammel Mary D, Putra Manesha
Аннотация
PURPOSE: Our primary objective was to characterize clinical and procedural factors affecting sample size in chorionic villus sampling (CVS).
METHODS: This retrospective, single-site cohort study included singleton pregnancies undergoing transabdominal (TA) and transcervical (TC) CVS between 2020 and 2023. Prenatal and maternal data were obtained from the electronic medical record. Differences by approach and sample size in relation to demographic and pregnancy characteristics were assessed. Linear regression was used to identify factors associated with yield.
RESULTS: Data from 240 CVS procedures were included (n = 91 TC CVS and n = 149 TA CVS). Sample size was significantly larger in TC compared to TA approach (37.1 mg vs 32.4 mg, p = 0.04). In unadjusted models, BMI was associated with a lower sample yield (p = 0.01); use of a TC approach was associated with higher sample size yield (p < 0.01); and lateral placenta was associated with significantly larger samples (p = 0.02). After adjusting for approach and placental location, higher BMI remained associated with smaller sample size (parameter estimate: - 0.47 mg (95% CI: - 0.86, - 0.08); p = 0.03).
CONCLUSION: CVS remains an important prenatal diagnostic tool in early gestation. We find that higher BMI is associated with a smaller sample yield despite differences in approach and placental location.
METHODS: This retrospective, single-site cohort study included singleton pregnancies undergoing transabdominal (TA) and transcervical (TC) CVS between 2020 and 2023. Prenatal and maternal data were obtained from the electronic medical record. Differences by approach and sample size in relation to demographic and pregnancy characteristics were assessed. Linear regression was used to identify factors associated with yield.
RESULTS: Data from 240 CVS procedures were included (n = 91 TC CVS and n = 149 TA CVS). Sample size was significantly larger in TC compared to TA approach (37.1 mg vs 32.4 mg, p = 0.04). In unadjusted models, BMI was associated with a lower sample yield (p = 0.01); use of a TC approach was associated with higher sample size yield (p < 0.01); and lateral placenta was associated with significantly larger samples (p = 0.02). After adjusting for approach and placental location, higher BMI remained associated with smaller sample size (parameter estimate: - 0.47 mg (95% CI: - 0.86, - 0.08); p = 0.03).
CONCLUSION: CVS remains an important prenatal diagnostic tool in early gestation. We find that higher BMI is associated with a smaller sample yield despite differences in approach and placental location.