Meta-analysis of race and age influence on the vaginal microbiome in pregnant and nonpregnant healthy women.

Aim: The presence of microbial species in reproductive tubes plays an essential protective role against the proliferation of harmful organisms and is an important factor in reproductive health. High-throughput culture-independent technologies allow the study of the vaginal microbiome on a large scale. This study aimed to compare the vaginal microbiota between pregnant and nonpregnant women of different ages and races using the meta-analysis method. Materials & methods: Seven articles with 16S rRNA gene sequences were studied and analyzed using CLC Genomics Workbench 20.1.1. Results & conclusion: This study revealed new insights into the effects of age and ethnicity on the pregnant and nonpregnant vaginal microbiome and found that the microbiome of Chinese women is more distinct than that of other ethnicities.