Ai zheng = Aizheng = Chinese journal of cancer · 2007
[Natural progression of early stage adenocarcinoma of gastric cardia: a report of seventeen cases].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Wang Guo-Qing, Wei Wen-Qiang, Zhang Jun-Hui
Аннотация
BACKGROUND & OBJECTIVE: The survival time of untreated advanced gastric cardiac adenocarcinoma patients is about 8-9 months. This study was to observe the natural progression of untreated early stage gastric cardiac adenocarcinoma.
METHODS: In 1987, at a high risk area of esophageal cancer, 851 patients with a previous cytologic diagnosis of esophageal dysplasia were re-examined by endoscopy, and 43 of them were diagnosed histologically as gastric cardiac adenocarcinoma. Of the 43 patients, 31 had early stage tumors, 12 had advanced tumors. The 17 early stage patients who refused treatment were followed up for 14 years till death.
RESULTS: Of the 17 untreated patients, 12 were died of gastric cardiac adenocarcinoma, 5 were died of non-cancer diseases; 13 had survived for over 5 years. The 5-year natural survival rate was 76.47%; the 10-year natural survival rate was 23.53%.
CONCLUSIONS: The progression of early stage cardiac cancer to advanced cancer is a very slow and long process, which is very helpful for early diagnosis and choice of therapeutic timing. The therapeutic effect on early stage cardiac cancer should be assessed with consideration of the natural history of this disease.
METHODS: In 1987, at a high risk area of esophageal cancer, 851 patients with a previous cytologic diagnosis of esophageal dysplasia were re-examined by endoscopy, and 43 of them were diagnosed histologically as gastric cardiac adenocarcinoma. Of the 43 patients, 31 had early stage tumors, 12 had advanced tumors. The 17 early stage patients who refused treatment were followed up for 14 years till death.
RESULTS: Of the 17 untreated patients, 12 were died of gastric cardiac adenocarcinoma, 5 were died of non-cancer diseases; 13 had survived for over 5 years. The 5-year natural survival rate was 76.47%; the 10-year natural survival rate was 23.53%.
CONCLUSIONS: The progression of early stage cardiac cancer to advanced cancer is a very slow and long process, which is very helpful for early diagnosis and choice of therapeutic timing. The therapeutic effect on early stage cardiac cancer should be assessed with consideration of the natural history of this disease.