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Nature genetics · 2015

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.

СтатьяМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Law Matthew H, Bishop D Timothy, Lee Jeffrey E, Brossard Myriam, Martin Nicholas G, Moses Eric K, Song Fengju, Barrett Jennifer H, Kumar Rajiv, Easton Douglas F, Pharoah Paul D P, Swerdlow Anthony J, Kypreou Katerina P, Taylor John C, Harland Mark, Randerson-Moor Juliette, Akslen Lars A, Andresen Per A, Avril Marie-Françoise, Azizi Esther, Scarrà Giovanna Bianchi, Brown Kevin M, Dębniak Tadeusz, Duffy David L, Elder David E, Fang Shenying, Friedman Eitan, Galan Pilar, Ghiorzo Paola, Gillanders Elizabeth M, Goldstein Alisa M, Gruis Nelleke A, Hansson Johan, Helsing Per, Hočevar Marko, Höiom Veronica, Ingvar Christian, Kanetsky Peter A, Chen Wei V, GenoMEL Consortium, Essen-Heidelberg Investigators, SDH Study Group, Q-MEGA and QTWIN Investigators, AMFS Investigators, ATHENS Melanoma Study Group, Landi Maria Teresa, Lang Julie, Lathrop G Mark, Lubiński Jan, Mackie Rona M, Mann Graham J, Molven Anders, Montgomery Grant W, Novaković Srdjan, Olsson Håkan, Puig Susana, Puig-Butille Joan Anton, Qureshi Abrar A, Radford-Smith Graham L, van der Stoep Nienke, van Doorn Remco, Whiteman David C, Craig Jamie E, Schadendorf Dirk, Simms Lisa A, Burdon Kathryn P, Nyholt Dale R, Pooley Karen A, Orr Nick, Stratigos Alexander J, Cust Anne E, Ward Sarah V, Hayward Nicholas K, Han Jiali, Schulze Hans-Joachim, Dunning Alison M, Bishop Julia A Newton, Demenais Florence, Amos Christopher I, MacGregor Stuart, Iles Mark M

Аннотация

Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10(-8)), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты