[Clinical importance of p53 gene mutation and PCNA expression in ureteral and renal pelvic cancers].

In order to know the clinical importance of p53 gene mutation and PCNA expression in ureteral and renal pelvic cancers, research was carried out with immunohistochemistry S-P method in 45 cases. Mutant p53 nuclear staining was positive in 24 cases (53.3%) and correlated with PCNA expression, being higher in clinical stages T3 and T4 than in T1 + T2. They also correlated with the grade of cell differentiation, being higher in G3 than in G1 + G2.