[Expression and clinical significance of PCNA in renal pelvic and ureteral cancer].

To determine the relationship between PCNA expression and pathological stage, cellular grade, recurrence and prognosis of renal pelvic and ureteral cancer, research on PCNA proliferating index in 47 cases of renal pelvic and ureteral cancer we studied by immunohistochemistry S-P method. PCNA proliferating index of renal pelvic and ureteral cancer increased with pathologic stage and cellular grade. PCNA proliferating index of T3 + T4 was significantly higher than that of T1 + T2 (P < 0.01). PCNA proliferating index of G3 was significantly higher than that of G1 + G2 (P < 0.001). Those with higher PCNA proliferating index (III + IV) had higher bladder cancer recurrent rate after operation (60%, 12/20), those with lower PCNA proliferating index (I + II) had lower bladder cancer recurrent rate (22.2%, 6/27). P < 0.01. 35% (7/20) of those with III + IV PCNA proliferating index had simultaneous polyorganic urothalial cancer, 7.4% (2/27) of those with I + II PCNA proliferating index had simultaneous polyorganic urothelial cancer, P < 0.05. 7.4% (2/27) of those with I + II PCNA proliferating index had local recurrence and metastasis after operation, 40% (8/20) of those with III + IV had local recurrence and metastasis, P < 0.05. The 5-year survival rate of I + II was 86.7%, the 5-year survival rated of III + IV was 35.7% (5/14), P < 0.05. The findings suggest that PCNA proliferating index connects with pathological stage and cellular grade of renal pelvic and ureteral cancer. It is an important characteristic of low differentiation, invasiveness and simultaneous or sequentially polyorganic urothelial cancer. It may be an important prognostic indicator of renal pelvic and ureteral cancer.