Leukemia & lymphoma · 2021
Treatment and outcome of newly diagnosed multiple myeloma patients > 75 years old: a retrospective analysis.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Al Saleh Abdullah S, Visram Alissa, Parmar Harsh, Muchtar Eli, Buadi Francis K, Dispenzieri Angela, Warsame Rahma, Lacy Martha Q, Dingli David, Leung Nelson, Go Ronald S, Gonsalves Wilson I, Kourelis Taxiarchis V, Hayman Suzanne R, Kapoor Prashant, Gertz Morie A, Kyle Robert A, Rajkumar S Vincent, Kumar Shaji K
Аннотация
This is a retrospective study of patients with multiple myeloma (MM) who were >75 years old. We identified 394 patients and for non-trial patients (n = 350), immunomodulatory drug (IMiD)+dex (32%) was the most commonly used regimen followed by alkylator with steroids or other therapy (21%), alkylator + proteasome inhibitor (PI)+steroid (18%), and IMiD + PI + dex (13%). Overall, achieving ≥ very good partial response was more in patients receiving a triplet compared to other therapies (46% vs. 21%, p < 0.0001). Also, the median overall survival (OS) was significantly longer in patients who were treated with a triplet (median OS: 50.2 vs. 32.8 months, p = 0.0006). In a multivariate for OS, receiving a triplet (HR: 0.65, p = 0.02), not having an R-ISS stage 3 (HR: 0.36, p = 0.0003), and bone marrow plasma cell percentage <60% (HR: 0.69, p = 0.03) were predictive. In conclusion, being able to receive triplet therapy was associated with better survival in our MM patients >75 years old.