Nippon Ganka Gakkai zasshi · 2002
[A case of follicular lymphoma derived from the conjunctiva].
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Azumi Atsushi, Hirai Koji, Tamura Yasushi, Saito Kazuko, Yamamoto Hiroyuki, Negi Akira, Obayashi Chiho
Аннотация
BACKGROUND: Follicular lymphoma, derived from ocular adnexa as defined by World Health Organization Classification of neoplastic diseases of the hematopoietic and lymphoid tissues, is quite rare in Japan.
CASE: A 65-year-old woman visited our clinic for treatment of a conjunctival tumor in the left eye.
FINDINGS: Incisional biopsy revealed that the lesion was a lymphoma with well-defined follicles, and it was L 26(CD20) and BCL-2 positive immunohistochemically. Flow cytometric analysis showed that more than 70% of the cells were double positive for CD10 and CD20. Southern blot hybridization demonstrated gene rearrangement bands in the immunoglobulin gene JH region. The chromosome had a translocation t(14, 18) (q32, q21). Systemic evaluation detected no other lymphoma.
CONCLUSION: The lesion was a follicular lymphoma derived from conjunctival tissue. Additional examinations such as flow cytometric analysis, gene analysis, and chromosome examination were useful for differential diagnosis of marginal zone B cell lymphoma of mucosa associated lymphoid tissue type and benign reactive lymphoid hyperplasia.
CASE: A 65-year-old woman visited our clinic for treatment of a conjunctival tumor in the left eye.
FINDINGS: Incisional biopsy revealed that the lesion was a lymphoma with well-defined follicles, and it was L 26(CD20) and BCL-2 positive immunohistochemically. Flow cytometric analysis showed that more than 70% of the cells were double positive for CD10 and CD20. Southern blot hybridization demonstrated gene rearrangement bands in the immunoglobulin gene JH region. The chromosome had a translocation t(14, 18) (q32, q21). Systemic evaluation detected no other lymphoma.
CONCLUSION: The lesion was a follicular lymphoma derived from conjunctival tissue. Additional examinations such as flow cytometric analysis, gene analysis, and chromosome examination were useful for differential diagnosis of marginal zone B cell lymphoma of mucosa associated lymphoid tissue type and benign reactive lymphoid hyperplasia.