[Recent progress in the management of malignant lymphoma].

In this article recent lymphoma-related topics were reviewed. REAL classification, a new histopathological classification of lymphoid neoplasm, has been controversial in terms of clinical usefulness. However, mantle cell lymphoma in the classification has been well established as one histopathological entity, and considered an intermediate grade lymphoma in prognosis. In gastric MALT lymphoma, Helicobacter pylori might provide the antigenic stimulus for its growth. The eradication of H. pylori causes regression of MALT lymphoma, and anti-H. pylori treatment should be given for this type of lymphoma. The international prognostic index has made it possible to make a different therapeutic plan according to the risk group. The results of new therapies, such as purine nucleoside analogs for low grade B cell lymphoma and high dose chemoradiotherapy for high grade aggressive lymphoma, were reviewed.