Leukemia & lymphoma · 2003
Hepatosplenic T-gammadelta lymphoma in a patient with Crohn's disease treated with azathioprine.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Navarro José-Tomás, Ribera Josep-Maria, Mate José-Luis, Granada Isabel, Juncà Jordi, Batlle Montserrat, Millá Fuensanta, Feliu Evarist
Аннотация
Hepatosplenic gammadelta T-cell lymphoma (HS-gammadeltaTCL) is an uncommon type of peripheral T-cell lymphoma, which has been associated in some cases with immunosuppression, mainly after solid organ transplants. We describe a case of HSgammadeltaTCL with a leukaemic course in a patient with Crohn's disease who had received azathioprine during the previous 5.5 years. Sinusoidal infiltration by atypical lymphocytes was observed in the liver, spleen and bone marrow and the typical cytogenetic abnormalities (isochromosome 7 and trisomy 8) were found. The patient did not respond to intensive chemotherapy. This case shows the importance of ruling out HSgammadeltaTCL in patients with hepatosplenomegaly, B-symptoms and any immunosuppressive condition.
Предметные рубрики MeSH
Adrenal Cortex HormonesAdultAntineoplastic Combined Chemotherapy ProtocolsAutoimmune DiseasesAzathioprineChromosome AberrationsCombined Modality TherapyCrohn DiseaseCyclophosphamideDoxorubicinDrug CombinationsFatal OutcomeGlucosamineHumansImmunophenotypingImmunosuppressive AgentsLiver NeoplasmsLymphoma, T-Cell, PeripheralMalePrednisoneReceptors, Antigen, T-Cell, gamma-deltaSplenectomySplenic NeoplasmsSulfasalazineVincristine