Clinical laboratory · 2025
Diagnostic and Prognostic Ability of Serum miR-411-3p in Patients with Acute Myeloid Leukemia.
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Chen Jun, Xu Mei-Rong, Yuan Jin-Bei, Liang Dong-Ping
Аннотация
BACKGROUND: This study aimed to identify the diagnostic and prognostic ability of serum miR-411-3p in patients with acute myeloid leukemia (AML).
METHODS: Blood samples were collected from 60 AML patients and 60 healthy controls to measure serum miR-411-3p and thereafter discuss its potential clinical value.
RESULTS: Serum miR-411-3p was decreased in AML patients and was even lower in those with M4/M5 subtypes or high white blood cell count or adverse cytogenetic risk. Serum miR-411-3p had a diagnostic value. An association existed between low serum miR-411-3p and worse clinical features and shorter survival, and miR-411-3p was able to predict overall survival and relapse-free survival in AML patients. In addition, serum miR-411-3p was upregulated after treatment, especially in AML patients who achieved complete remission.
CONCLUSIONS: Serum miR-411-3p is of promising utility regarding AML diagnosis and prognosis.
METHODS: Blood samples were collected from 60 AML patients and 60 healthy controls to measure serum miR-411-3p and thereafter discuss its potential clinical value.
RESULTS: Serum miR-411-3p was decreased in AML patients and was even lower in those with M4/M5 subtypes or high white blood cell count or adverse cytogenetic risk. Serum miR-411-3p had a diagnostic value. An association existed between low serum miR-411-3p and worse clinical features and shorter survival, and miR-411-3p was able to predict overall survival and relapse-free survival in AML patients. In addition, serum miR-411-3p was upregulated after treatment, especially in AML patients who achieved complete remission.
CONCLUSIONS: Serum miR-411-3p is of promising utility regarding AML diagnosis and prognosis.