Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2013
Recurrence of nasopharyngeal carcinoma in the parotid region after definitive intensity-modulated radiotherapy.
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Cao Cai-Neng, Luo Jing-Wei, Gao Li, Xu Guo-Zhen, Li Su-Yan, Xiao Jian-Ping
Аннотация
PURPOSE: To discuss the clinical characteristics and management of periparotid recurrence of nasopharyngeal carcinoma after definitive intensity-modulated radiotherapy.
PATIENTS AND METHODS: The authors retrospectively reviewed the charts of 716 patients with nasopharyngeal carcinoma who underwent intensity-modulated radiotherapy at their center from January 2005 through December 2010. Disease recurred in a spared parotid gland in 10 patients (1.4%). After periparotid recurrence, 4 patients received surgery alone, 1 patient received radiotherapy alone, 2 patients received chemotherapy alone, 2 patients received surgery plus chemotherapy, and 1 patient received surgery plus radiotherapy.
RESULTS: After a median follow-up of 42.6 months (19.8 to 86.0 months), 4 patients died of tumor progression. The median survival time after periparotid recurrence was 25.1 months (5.0 to 74.5 months).
CONCLUSIONS: Periparotid recurrence is an uncommon pattern of failure after definitive intensity-modulated radiotherapy for nasopharyngeal carcinoma, and there were some long-term survivors in this patient population after salvage treatment.
PATIENTS AND METHODS: The authors retrospectively reviewed the charts of 716 patients with nasopharyngeal carcinoma who underwent intensity-modulated radiotherapy at their center from January 2005 through December 2010. Disease recurred in a spared parotid gland in 10 patients (1.4%). After periparotid recurrence, 4 patients received surgery alone, 1 patient received radiotherapy alone, 2 patients received chemotherapy alone, 2 patients received surgery plus chemotherapy, and 1 patient received surgery plus radiotherapy.
RESULTS: After a median follow-up of 42.6 months (19.8 to 86.0 months), 4 patients died of tumor progression. The median survival time after periparotid recurrence was 25.1 months (5.0 to 74.5 months).
CONCLUSIONS: Periparotid recurrence is an uncommon pattern of failure after definitive intensity-modulated radiotherapy for nasopharyngeal carcinoma, and there were some long-term survivors in this patient population after salvage treatment.
Предметные рубрики MeSH
AdultAntineoplastic Combined Chemotherapy ProtocolsCarcinomaChemotherapy, AdjuvantDisease ProgressionFemaleFollow-Up StudiesHumansLymphatic MetastasisMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNeck DissectionNeoplasm StagingPalliative CareParotid GlandParotid NeoplasmsRadiotherapy, AdjuvantRadiotherapy, Intensity-ModulatedRetrospective StudiesSalvage TherapySurvival Rate