Internal medicine (Tokyo, Japan) · 2021
The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis.
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Kondo Tatsuya, Kitano Sayaka, Miyakawa Nobukazu, Watanabe Takuro, Goto Rieko, Sato Miki, Hanatani Satoko, Sakaguchi Masaji, Igata Motoyuki, Kawashima Junji, Motoshima Hiroyuki, Matsumura Takeshi, Araki Eiichi
Аннотация
The gastrointestinal tract is considered an important endocrine organ for controlling glucose homeostasis via the production of incretins. A 21-year-old man emergently underwent total colectomy due to severe ulcerative colitis, and overt diabetes became evident. Weekly administration of a glucagon-like peptide (GLP)-1 receptor agonist (RA) dramatically improved his glucose control. Levels of GLP-1 or gastric inhibitory polypeptide (GIP) were low at the baseline in the duodenum and serum of the patient. After 11 months of GLP-1RA treatment, his HbA1c worsened again, and intensive insulin therapy was necessary to control his glucose levels. Our report may explain the significance of residual incretin for maintaining the pancreatic β-cell function.