Prevalence and factors associated with organic dyspepsia in older adults with dyspepsia.

This study aimed to report findings from EGD investigations in older adults with dyspepsia and identify factors associated with organic dyspepsia in this population. We conducted a retrospective cross-sectional study at a tertiary care center in Northern Thailand. Medical records of adults aged 50 years and older presenting with dyspepsia who underwent initial EGD between January 2018 and December 2022 were reviewed. Organic dyspepsia includes erosive esophagitis, ulcer, mass, and cancerous lesions. Multivariable logistic regression was used to identify factors associated with organic dyspepsia. Data from 466 patients were analyzed. Functional dyspepsia was the predominant diagnosis (94.0%), while organic dyspepsia was diagnosed in 6.0% of patients. Gastric/duodenal ulcer, erosive esophagitis, and gastric malignancy accounted for 1.9%, 1.7%, and 1.1% of cases, respectively. After adjustment for covariates, a low body mass index (BMI of less than 18.5 kg/m2) and male gender significantly increased the likelihood of organic dyspepsia, with an adjusted odds ratio (OR) of 4.34; 95% CI 1.45-12.09, p=0.009 and adjusted OR of 2.64; 95% CI 1.13-6.17, p=0.024, respectively. There were no significant associations found between other factors and organic dyspepsia, including age, smoking, alcohol use, symptom duration, H. pylori infection, and NSAID use.