Journal of the Turkish German Gynecological Association · 2018
Association between fok1 polymorphism of vitamin D receptor gene with uterine leiomyoma in Turkish populations.
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Güleç Yılmaz Seda, Gül Tuğçe, Attar Rukset, Yıldırım Gazi, İşbir Turgay
Аннотация
OBJECTIVE: The aim of this research was to determine the association between the fok1 polymorphism and uterine leiomyomas.
MATERIAL AND METHODS: For genotyping the fok1 polymorphism of the vitamin D receptor, real-time polymerase chain reaction was performed on blood samples of uterine leiomyoma (n=27) and control (n=33) groups. For statistical analyses, SPSS v.23 software (SPSS Inc., Chicago, IL, USA) was used.
RESULTS: A statistically significant difference was observed for the frequency of the CC genotype between the uterine leiomyoma and control groups, and the frequencies of the T allele in the uterine leiomyoma groups were significantly higher than in the control group.
CONCLUSION: The presence of the fok1 CC genotype may be a risk-reducing factor and the T allele may be a potential risk factor for developing uterine leiomyoma.
MATERIAL AND METHODS: For genotyping the fok1 polymorphism of the vitamin D receptor, real-time polymerase chain reaction was performed on blood samples of uterine leiomyoma (n=27) and control (n=33) groups. For statistical analyses, SPSS v.23 software (SPSS Inc., Chicago, IL, USA) was used.
RESULTS: A statistically significant difference was observed for the frequency of the CC genotype between the uterine leiomyoma and control groups, and the frequencies of the T allele in the uterine leiomyoma groups were significantly higher than in the control group.
CONCLUSION: The presence of the fok1 CC genotype may be a risk-reducing factor and the T allele may be a potential risk factor for developing uterine leiomyoma.