Cancer treatment and research communications · 2025
Analysis of the relevant factors of lymph node metastasis in No.253 lymph node of rectal cancer patients.
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Gao Yu-Xi, Pan Shi-Xiang, Hu Fang, Li Bo, Wang Shou-Guang
Аннотация
OBJECTIVE: Lymph node metastasis is the primary metastasis of colorectal cancer, and it is of positive significance to explore the characteristics and potential influencing factors of lymph node metastasis in colorectal cancer patients to guide the treatment and improve the prognosis of patients.
METHOD: The clinical data of 760 patients with rectal cancer (D3) who underwent radical rectal cancer (D3) resection in the Affiliated Hospital of Qingdao University from October 2017 to October 2022 were retrospectively analysed.
RESULT: Among the 760 patients, 314 was lymph node-positive, of which 26 was positive for the No.253 lymph node. Univariate analysis showed that CEA level, tumor T stage, tumor N stage, number of lymph nodes metastasised, and vascular tumor thrombus were risk factors for lymph node metastasis in No.253 lymph node of rectal cancer. Multivariate analysis showed that CEA level (CEA>5 ng/ml), number of lymph nodes metastasised, and vascular cancer thrombus were independent risk factors for lymph node metastasis in No.253 lymph node of rectal cancer patients.
CONCLUSION: The risk of lymph node metastasis in No.253 lymph node was higher in rectal cancer patients with high CEA levels, late tumor TNM stage, number of lymph node metastases, and positive vascular thrombus. CEA level (CEA>5 ng/ml), number of lymph nodes metastasised, and vascular cancer thrombus were independent risk factors for lymph node metastasis in No.253 lymph node of rectal cancer patients.
METHOD: The clinical data of 760 patients with rectal cancer (D3) who underwent radical rectal cancer (D3) resection in the Affiliated Hospital of Qingdao University from October 2017 to October 2022 were retrospectively analysed.
RESULT: Among the 760 patients, 314 was lymph node-positive, of which 26 was positive for the No.253 lymph node. Univariate analysis showed that CEA level, tumor T stage, tumor N stage, number of lymph nodes metastasised, and vascular tumor thrombus were risk factors for lymph node metastasis in No.253 lymph node of rectal cancer. Multivariate analysis showed that CEA level (CEA>5 ng/ml), number of lymph nodes metastasised, and vascular cancer thrombus were independent risk factors for lymph node metastasis in No.253 lymph node of rectal cancer patients.
CONCLUSION: The risk of lymph node metastasis in No.253 lymph node was higher in rectal cancer patients with high CEA levels, late tumor TNM stage, number of lymph node metastases, and positive vascular thrombus. CEA level (CEA>5 ng/ml), number of lymph nodes metastasised, and vascular cancer thrombus were independent risk factors for lymph node metastasis in No.253 lymph node of rectal cancer patients.