Scientific reports · 2017
Changes in hyaluronan deposition in the rat myenteric plexus after experimentally-induced colitis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Filpa Viviana, Bistoletti Michela, Caon Ilaria, Moro Elisabetta, Grimaldi Annalisa, Moretto Paola, Baj Andreina, Giron Maria Cecilia, Karousou Evgenia, Viola Manuela, Crema Francesca, Frigo Gianmario, Passi Alberto, Giaroni Cristina, Vigetti Davide
Аннотация
Myenteric plexus alterations hamper gastrointestinal motor function during intestinal inflammation. Hyaluronan (HA), an extracellular matrix glycosaminoglycan involved in inflammatory responses, may play a role in this process. In the colon of control rats, HA-binding protein (HABP), was detected in myenteric neuron soma, perineuronal space and ganglia surfaces. Prominent hyaluronan synthase 2 (HAS2) staining was found in myenteric neuron cytoplasm, suggesting that myenteric neurons produce HA. In the myenteric plexus of rats with 2, 4-dinitrobenzene sulfonic (DNBS)-induced colitis HABP staining was altered in the perineuronal space, while both HABP staining and HA levels increased in the muscularis propria. HAS2 immunopositive myenteric neurons and HAS2 mRNA and protein levels also increased. Overall, these observations suggest that inflammation alters HA distribution and levels in the gut neuromuscular compartment. Such changes may contribute to alterations in the myenteric plexus.