[CME: Pheochromocytoma in the General Practice].

CME: Pheochromocytoma in the General Practice Abstract. Pheochromocytoma are rare tumors, usually symptomatic due to their hormonal activity with excessive catecholamine secretion. Because of their bright spectrum of clinical presentation, they are often undiagnosed. The first diagnostic step is biochemical screening with measurement of free metanephrines in plasma or fractionated metanephrines in 24-hours urine. Knowledge about measurement method used and potential preanalytical factors leading to false results, are necessary for the interpretation. Tumor localisation (imaging) is performed after biochemical evidence of the tumor is present. Laparoscopic surgery is for the majority of cases the primary therapy and curative. Lifelong biochemical follow-up is necessary, with additional tests in case of hereditary tumors.